Operation Delirium: a secret Cold War chemical weapons testing program conducted by the US Army during the 1950s and ’60s

Raffi Khatchadourian, Operation Delirium. The New Yorker, 17 December 2012. “Military doctors who helped conduct the [psychochemical] experiments [during the 1950s and ’60s] have long since moved on, or passed away, and the soldiers who served as their test subjects—in all, nearly five thousand of them—are scattered throughout the country, if they are still alive. Within the Army, and in the world of medical research, the secret clinical trials are a faint memory. But for some of the surviving test subjects, and for the doctors who tested them, what happened at Edgewood remains deeply unresolved. Were the human experiments there a Dachau-like horror, or were they sound and necessary science?” Companion piece to Operation Delirium: High Anxiety: LSD in the Cold War by Raffi Khatchadourian, The New Yorker, 16 December 2012. “For decades, the U.S. Army conducted secret clinical experiments with psychochemicals at Edgewood Arsenal. In the nineteen-sixties, Army Intelligence expanded the arsenal’s work on LSD, testing the drug as an enhanced-interrogation [torture] technique in Europe and Asia. This companion piece to “Operation Delirium”…documents the people who were involved and what they did.” Primary Sources : Operation Delirium, The New Yorker, 26 December 2012.

Excerpts from story:

Colonel James S. Ketchum dreamed of war without killing. He joined the Army in 1956 and left it in 1976, and in that time he did not fight in Vietnam; he did not invade the Bay of Pigs; he did not guard Western Europe with tanks, or help build nuclear launch sites beneath the Arctic ice. Instead, he became the military’s leading expert in a secret Cold War experiment: to fight enemies with clouds of psychochemicals that temporarily incapacitate the mind—causing, in the words of one ranking officer, a “selective malfunctioning of the human machine.” For nearly a decade, Ketchum, a psychiatrist, went about his work in the belief that chemicals are more humane instruments of warfare than bullets and shrapnel—or, at least, he told himself such things. To achieve his dream, he worked tirelessly at a secluded Army research facility, testing chemical weapons on hundreds of healthy soldiers, and thinking all along that he was doing good.

Today [2012], Ketchum is eighty-one years old, and the facility where he worked, Edgewood Arsenal, is a crumbling assemblage of buildings attached to a military proving ground on the Chesapeake Bay. The arsenal’s records are boxed and dusting over in the National Archives. Military doctors who helped conduct the experiments have long since moved on, or passed away, and the soldiers who served as their test subjects—in all, nearly five thousand of them—are scattered throughout the country, if they are still alive. Within the Army, and in the world of medical research, the secret clinical trials are a faint memory. But for some of the surviving test subjects, and for the doctors who tested them, what happened at Edgewood remains deeply unresolved. Were the human experiments there a Dachau-like horror, or were they sound and necessary science? As veterans of the tests have come forward, their unanswered questions have slowly gathered into a kind of historical undertow, and Ketchum, more than anyone else, has been caught in its pull. In 2006, he self-published a memoir, “Chemical Warfare: Secrets Almost Forgotten,” which defended the research. Next year [2013], a class-action lawsuit brought against the federal government by former test subjects will go to trial, and Ketchum is expected to be the star witness.

The lawsuit’s argument is in line with broader criticisms of Edgewood: that, whether out of military urgency or scientific dabbling, the Army recklessly endangered the lives of its soldiers—naïve men, mostly, who were deceived or pressured into submitting to the risky experiments. The drugs under review ranged from tear gas and LSD to highly lethal nerve agents, like VX, a substance developed at Edgewood and, later, sought by Saddam Hussein. Ketchum’s specialty was a family of molecules that block a key neurotransmitter, causing delirium. The drugs were known mainly by Army codes, with their true formulas classified. The soldiers were never told what they were given, or what the specific effects might be, and the Army made no effort to track how they did afterward. Edgewood’s most extreme critics raise the spectre of mass injury—a hidden American tragedy….

For many doctors at Edgewood, the memory of the Second World War, and the horrific experiments carried out by Nazi scientists, remained potent. After the war, the Nuremberg Code established an ethical framework for medical experiments, and its principles were incorporated into Army doctrine. The code begins with a clear premise: “The voluntary consent of the human subject is absolutely essential.” That consent must flow from an “enlightened decision,” shaped by a true understanding of the test’s medical risks. Moreover, human experiments must be preceded by animal studies, and conducted in pursuit of a greater social good—with risks never exceeding “the humanitarian importance of the problem.” If a subject is unable to endure the experiment, or if a researcher believes there is a probability of injury, the test must end….

In 1961, a volunteer from Kansas, named John Ross, was given soman, a highly persistent nerve agent. Only when the needle was in his arm did he overhear the doctors saying that he had been given something lethal. “I started having convulsions,” he told me. “I started vomiting. One of the guys standing over me said, ‘We gave you a little too much.’ They told me to walk it off. I started to panic. I thought I was going to die.” Ross became rigid and was rushed to Walter Reed. For years afterward, he suffered from insomnia and depression….

A physician named Mark Needle told me that he thought Ketchum’s human experiments were run like the Keystone Kops. “There was nobody qualified,” he said. “And the fact that they were allowed to do it without people who knew what they were doing was very, very scary. There was no humanity in it. There was no morality in it. If anything happened to the volunteers, we could say, ‘You were offered an out,’ but then we were also telling them, ‘Listen, this is the Army, and we are at war.’ Our view was that this was a terrible thing to do to these kids, because who the hell knew what could happen?”…

In a press release about the lawsuit, Morrison & Foerster called the experiments “diabolical.” Whether such a term is accurate may ultimately come to rest on one question: were the rights of the test subjects abused? The precepts set forth in the Nuremberg Code are at the heart of the lawsuit….